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Chemistry and biote...
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Biotechnology


Chemical Engineering and Technology


Chemistry


Fibre and Polymer Technology


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Bacterial surface display (»Add to Infobox)

Research Leader: Professor Stefan Sthl
Filippa Fleetwood, Nina Kronqvist, Hanna Lindberg, John Lfblom, Magdalena Malm


Molecular Biotechnology

The group has during the last two decades developed novel host vector systems for efficient surface display on food-grade staphylococci, e.g., Staphylococcus carnosus, and described how the systems may be successfully used for subunit vaccine delivery, or as whole cell tools for diagnostic or environmental applications. The present focus is on the evaluation of the staphylococcal display systems for protein library applications, employing fluorescence-activated cell sorting (FACS) for library screening for selection of novel binding proteins, e.g. affibody molecules and nanobodies. Recently, the staphylococcal system has also been successfully employed for epitope mapping of polyclonal and monoclonal antibodies. The group has published some 40 articles on these subjects, and eight PhDs have so far based their dissertation on this research.

Period: 1990-06-30 - 2012-12-31

Keywords:
Bacterial display, Epitope mapping, FACS, Protein engineering, Selection system, Staphylococci

SOURCE OF FUNDING (2/2) 

VINNOVA (The Swedish Agency for Innovation Systems)

VR (The Swedish Research Council)


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