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3g-Nanotechnology based targeted drug delivery using the inner ear as a model target organ – NANOEAR (»Add to Infobox)

Research Leader: Professor Mamoun Muhammed


Materials and Nanophysics

The purpose of this project is to develop the third generation multifunctional nanoparticles (3gMFNP), which are targetable, biodegradable, traceable in vivo and equipped with controlled drug release. The target organ is the inner ear and the target population the 44 million EU citizens with treatable hearing loss and the 40 000 profoundly deaf.

The purpose of this project is to develop the third-generation multifunctional nanoparticles, which are targetable, biodegradable, traceable in vivo and equipped with controlled drug release. The target organ is the inner ear and the target population the 44 million EU citizens with treatable hearing loss and the 40 000 profoundly deaf.

The inner ear is a clinically vital target, well representing the central nervous system and difficult-to-access body sites; it is isolated, multi-compartmental with neural, supporting and vascular targets, and relatively immune-privileged. Novel, multifunctional, highly penetrating delivery vehicles will be created to carry and release drugs precisely to targeted tissue sites and selected cells. Multifunctional NPs, dendrimers, micelles, nanolayers and polymer-protein complexes will be designed for delivery of molecules/drugs to selected target cells and tissues of the inner ear.

Four EU/FDA approved degradable biomaterials (PLGA, PCL, chitosan, silica) will be tested. In addition commercially available liposomes, encapsulated by polyethylene glycol (mPEG), impregnated with drugs, and decorated with targeting ligands and signalling molecules will be assessed for benchmarking purposes. These data will provide the reference for evaluating novel multi functional nanoparticles.

The fabricated NPs will be applicable to a wide variety of drugs (e.g. conventional therapeutics, growth factors, proteins and, nucleic acids) to increase selectivity, reduce side effects and enhance efficacy more than possible with current drug delivery, allowing treatments hitherto not possible.

Besides 19 universities and research institutes, five commercial SMEs are partners in this project, each bringing special knowledge and specific market concerns. The “nanosizing” of drugs brings benefits of control of surface area, solubility, rate of dissolution, bioavailability, onset of therapeutic action, stability and targeting (selectivity), with subsequent clinical benefits of decrease in necessary dose, fed/fasted variability, reduced patient variability, and increased control of drug distribution.



Period: 2006-11-01 - 2011-10-31

Keywords:
Drug delivery, Ear, Magnetic Resonance Imaging, Nanoparticles

Project URL:
http://www.nanoear.org/

SOURCE OF FUNDING (1/1) 

European Commission


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